Editorial and Commission Artwork — Allison Bruce

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A. K. BRUCE DESIGN

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Editorial and Commission Artwork

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Commissioned artwork
for ORIC Pharmaceuticals

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Image depicting a branching glycogen molecule against the backdrop of muscle fibers, evoking the buildup of glycogen in muscle tissue that occurs in Pompe disease. Julie C. Ullman, Eric M. Green et al., Science Translational Medicine, v16 n730

This image aims to depict a new day for the cancer-immunity cycle, noting both the permanence of this conceptual framework and the v56, n10continuous progress in the field. Ira Mellman,Daniel S. Chen et al., Cell Genomics, v56, n10 Adobe Illust

Orozco et al. explore a systems-biology approach that uncovers novel disease mechanisms in age-related macular degeneration. The cover depicts an artist’s representation of a fundus image of a human retina with age-related macular degeneration. The

Image illustrating several stages of cell division or mitosis. The stages illustrated here include interphase, prophase, metaphase, anaphase, and telophase. BioImages 2022 : Premier Award winner (Natural Science Illustration category) and Best of

Human enzymes glycogenin (orange) and glycogen synthase (turquoise) cooperate to synthesize glycogen in muscle. Fastman et al. resolved multiple cryo-EM structures of the enzyme complex that correspond to different functional states. An intermediate

Olarte et al. describe two pathways, the CYTOLD and ERTOLD pathways, for directing protein to the surface of lipid droplets (LDs). The cover is an artistic depiction of lipid droplets budding from the endoplasmic reticulum (ER). During LD formation,

T cell accumulation in the inflamed gut is an important aspect of the pathobiology of inflammatory bowel disease. Blockade of both a4b7 and aEb7 is more effective at reducing T cells in the gut than blockade of a4b7 alone by decreasing cell retentio

The sodium-chloride cotransporter (NCC) is central to sodium handling by the kidney and is the target of a clinically important class of drugs for hypertension, thiazide diuretics. Structures of human NCC with and without a bound thiazide diuretic (

Kuzuoglu-Ozturk et al. perform a genome-wide CRISPRi screen in cells expressing Myc and Ras to identify synthetic lethal partners of the major cap binding protein, eIF4E, that sustain cancer cell viability. They identify several functional connectio

Bashore et al. discover a series of cyanopyrrolidine inhibitors of the deubiquitinase USP7 that, as expected, form a covalent cysteine adduct, but surprisingly induce a subsequent β-elimination that leads to desulfurization of the active-site cystei

Painting of a human retina. Orozco et al. identified 15 putative causal genes for age-related macular degeneration, using a single-nucleus atlas, and genetics of human ocular transcriptomes. Orozco et al., Cell Reports , v30 n4 Alcohol ink, Ad

Illustration done for a paper on the Indian cobra reference genome and how transcriptome enables identification of venom toxins. Adobe Illustrator, Photoshop

Glutaminase inhibitors sensitize chemoresistant pancreatic cancer cells to gemcitabine, thereby improving the effectiveness of chemotherapy. This therapeutic approach holds promise as a novel therapy for pancreatic cancer patients harboring KRAS mut

Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain Ultsch, et al., Journal of Molecular Biology , Vol 431 No 5 PyMOL, Blender, Adobe Photoshop

Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors. Style inspired by the illustrations of Rube Goldberg. Yen et al., Cancer Cell , v34 n4 Graphite, Adobe Photoshop

Immune Cells Alcohol inks, Adobe Photoshop

Cell Structures and Interactions Alcohol inks, Adobe Photoshop

The cover depicts a Wnt protein (white dots) interacting with a Frizzled (Fzd)-expressing intestinal crypt containing intestinal stem cells (yellow beads), paneth cells (orange beads), transit amplifying cells (blue beads) and enterocytes (gray bead

Li et al. developed an anti-FcRH5/CD3 T-cell-dependent bi-specific (TDB) antibody for multiple myeloma immunotherapy. The image depicts a T cell (green) in the process of releasing lytic granules (red/magenta), which cause apoptosis of the cancer ce

The cover shows an artists impression of cancer stem cells metastasizing through the blood stream. Cancer stem cells are thought to be the driving force behind tumour growth and metastatic dissemination, but experimental evidence is lacking for many

Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular AMD. Koenig et al.,  JBC , v290 n36 PyMOL, Adobe Illustrator, Photoshop

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex Kolumam et al., EBioMedicine , v2 n7 Alcohol inks, Adobe Photoshop

A tumour cell (left) interacts with three T cells and a tumour-infiltrating immune cell. Powels et al.,  Nature, v515 n7528 Graphite, Adobe Photoshop

Synapses on pyramidal neurons, with spinal structures (L) and without (R) Graphite, Adobe Photoshop

The cover depicts the suppression of antitumor CD8+ T cell responses by the coinhibitory receptor TIGIT, which deprives CD8+ T cells of costimulation through the complementary receptor CD226. Johnston et al.,  Cancer Cell , v26 n6 Gra

Crossing the Rubicon - Breaking Through the Blood-Brain Barriar Atwal et al. and Yu et al.,  Science Translational Medicine ,  v3 n84 Maya, PyMOL, Adobe Photoshop

Jung-Hua Yeh et al.,  Cell , v132 n5 Maya, Adobe Photoshop

Editorial and Commission Artwork | Instructional Illustration | Graphic Design

All artwork featured on this website is copyright protected. For more information, please contact allison@akbruce.com